CHEK1 antibody

Catalog No. ABIN5703772

This Rabbit Polyclonal antibody specifically detects CHEK1 in WB, ELISA, IF and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for CHEK1 antibody (ABIN5703772)

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHEK1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-CHEK1 Antibody

Purpose: CHEK1 antibody

Immunogen: CHK1 checkpoint homolog (S. pombe)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for CHEK1

Target: CHEK1 (Checkpoint Kinase 1 (CHEK1))

Alternative Name: CHEK1

Background:

Synonyms: Serine/threonine-protein kinase Chk1|CHK1 checkpoint homolog|Cell cycle checkpoint kinase|Checkpoint kinase-1|CHEK1|CHK1

Background: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.

Molecular Weight: 50-55 kDa

Pathways: p53 Signaling, Apoptosis, Cell Division Cycle, DNA Damage Repair